منابع مشابه
UCS Proteins: Managing the Myosin Motor
Recent studies indicate that myosin molecular motors interact inside cells with proteins containing a conserved 'UCS' domain. This appears to ensure proper folding of myosin heads so that they can perform their ATP-dependent actin-based motor functions.
متن کاملMyosin V motor proteins
Mammalian myosin V motors transport cargo processively along actin filaments. Recent biophysical and structural studies have led to a detailed understanding of the mechanism of myosin V, making it perhaps the best understood cytoskeletal motor. In addition to describing the mechanism, this review will illustrate how "dynamic" single molecule measurements can synergize with "static" protein stru...
متن کاملMotor Proteins: Myosin Mechanosensors
Mechanosensation is emerging as a general principle of myosin motors. As demonstrated in a recent study, the single-headed myosin I molecule is an exquisite mechanosensor, able to sense strain over a very small force range.
متن کاملThe UCS family of myosin chaperones.
The canonical UCS (UNC-45/Cro1/She4p) protein, Caenorhabditis elegans UNC-45, was one of the earliest molecules to be shown genetically to be necessary for sarcomere assembly. Genetic analyses of homologues in several fungal species indicate that the conserved UCS domain functionally interacts with conventional type II and unconventional type V myosins. In C. elegans and other invertebrate spec...
متن کاملMotor proteins: Myosin V – the multi-purpose transport motor
Studies in yeast and mice suggest that myosin V participates in the directed transport of a number of distinct cargos to polarized regions of the cell; myosin V has also been implicated in the provision of materials for filopodial extension in neurons.
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ژورنال
عنوان ژورنال: Current Biology
سال: 2003
ISSN: 0960-9822
DOI: 10.1016/s0960-9822(03)00447-0